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There is often a delay in diagnosing Parkinson s disease The early symptoms of Parkinson s disease can be vague (see box) The signs are usually asymmetrical, leading to confusion with strokes and tumours The core features of Parkinson s disease are bradykinesia and rigidity Bradykinesia is a lack of spontaneous movements (often most noticeable as reduced blinking, lack of facial expression and reduced arm swing when walking), and a slowing of movements, especially ne repetitive ones Rigidity is an increase in tone throughout the full range of movement, unlike spasticity which builds up and then gives way Rigidity may have a constant resistance (like bending a lead pipe) or a juddering feel (like turning a cogwheel against a ratchet).

As previously mentioned, XML stresses the separation of content from presentation. This appendix uses CSS for XML document display. However, a strong up-and-coming contender for XML display is XSL, the Extensible Style Language. XSL, an XML application, consists of a transformation language and a formatting language. The transformation language specifies how one XML document may be transformed into another for example, how the custom tags used in an XML document may be changed to tags of another. The formatting language, similar to CSS, describes how an XML document is rendered. XML developers can mix and match tags from multiple applications. However, a mechanism needs to be in place to enable XML applications to distinguish between elements and attributes of the same name. A related XML technology called Namespaces enables an XML developer to prefix custom tags by directing the XML parser to reference a unique resource (dataset, URL). The XML community is crying out for more robust technologies than DTDs to perform XML document structure and element/attribute validations. XML Schemas is an attempt to provide database-like validations, such as data types, to XML elements. With the proliferation of Web pages on the Internet, technology that facilitates quick and accurate searches is in increasing demand. The XML application RDF, the Resource Description Framework, encodes data about data, or metadata. In other words, RDF provides a consistent way to describe metadata. The basic idea is that RDF standardizes vocabularies used to describe metadata and should provide a strong foundation for building applications to search XML documents.

The rest tremor of Parkinson s disease (in the limbs, the jaw or the lightly closed eyes) is highly characteristic, but 50% of patients do not have it at presentation and 20% never get it Gait disturbance is usually mild in the rst few years Patients may then develop dif culty in starting to walk or in stopping (festination) or may abruptly freeze in doorways or crowds Eventually most patients have falls The falling is partly a consequence of slow, stiff muscles or freezing, but partly also due to a failure of more complex postural righting re exes or orthostatic hypotension It has a very bad effect on quality of life Non-motor symptoms are often equally distressing, especially depression, dementia and disturbed sleep Depression has a prevalence of 30% and should be actively sought and treated Dementia is unusual before 70 years but affects many patients thereafter.

Icchok Nyssenbaum, the rabbi leader of the Mizrachi and a member of the Warsaw underground He perished in Treblinka The members of the Bund who died in the Ghetto Uprising also have a plaque Another, in the form of a manhole cover, memorializes the sewers through which Jewish inhabitants clandestinely entered and escaped from the ghetto; still another is dedicated to Shmul Zygelbojm, a member of the Warsaw Ghetto s rst Jewish council He escaped but later committed suicide in London his way of protesting the world s indifference to the Holocaust His nal words were addressed to the exiled president of Poland: I cannot remain silent, nor can I remain alive, while the last remnants of the Jewish people perish in Poland The plaques and monuments house the ghosts of those who lived and perished here Their silence speaks volumes.

Allowing Markets to Reach Socially Optimal Outcomes ........................ 316 Examining Externalities: The Costs and Benefits Others Feel from Our Actions ................................................................ 317 Defining positive and negative externalities .................................. 318 Noting the effects of negative externalities .................................... 318 Realising that you want positive amounts of negative externalities ................................................................ 320 Dealing with negative externalities.................................................. 321 Calculating the consequences of positive externalities ............... 322 Taking in the Tragedy of the Commons ................................................... 324 Having a cow: Overgrazing on a commonly owned field .............. 324 Sleeping with the fishes: Extinctions caused by poor property rights ................................................... 326