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Table 5.3 Research methods of assessing serotonin function Pharmacological challenge strategy Administration of an agent (e.g. mCPP, fen uramine, L-tryptophan) with serotonin-speci c properties and the subsequent assessment of changes in behavior or hormonal release (e.g. prolactin). Measure of hypothalamic pituitary neuroendocrine responsiveness Acute tryptophan depletion Methodology that induces a rapid and substantial lowering of plasma tryptophan levels and markedly reduces brain 5-HT synthesis in humans followed by the examination of behavioral responses (mood, urge to eat, food consumption) Platelet measures of serotonin function Peripheral measures of 5-HT activity as an indirect means of assessing central 5-HT function: 3 H-imipramine binding, platelet uptake of serotonin, serotonin-ampli ed platelet aggregation, serotonin-induced platelet calcium mobilization, 3 H-LSD binding, platelet MAO activity Precursor and metabolite studies Tryptophan levels and plasma TRP/LNAA ratio, CSF concentrations of 5-HIAA, the major metabolite of serotonin Treatment trials with serotonergic agents Serotonin antagonists (cyproheptadine), serotonin agonists (SSRIs)

One criticism of the above method is that the incremental load is de ned in an arti cial manner. This allows for a simple solution method, but places an arti cial constraint on the problem; a solution with this arti cial constraint is not as good as one without this constraint. Below, we pose a more robust formulation of the problem that leads to an improved solution. 5.4.7.1 In Words

With programmatic transaction demarcation (often called bean-managed transaction demarcation), the EJB developer is responsible for defining the boundaries of the transaction. Your code should expose methods that start the transaction, perform all required operations, and commit or abort the transaction. In short, bean-managed demarcation is the traditional way of coding transaction-driven applications. You might be wondering what, with bean-managed transaction demarcation, is the benefit to using Enterprise JavaBeans. Well, you still have the benefits afforded by a distributed object manager, such as location transparency. Also, you need not fret over coding the details of having the transaction manager coordinate efforts with the resource managers during the execution of the transaction operations. You write code invoking methods that implement the operations required to complete the transaction; the EJB container and server handle the coordination of the system components needed to complete (or abort) the transaction. With bean-managed transaction demarcation, the enterprise bean code demarcates transactions using the javax.transaction.UserTransaction interface. All resource manager accesses between the UserTransaction.begin and UserTransaction.commit calls are part of a transaction. Hence, your beans

1 Management of the space within a frame We do not tell a couple what to do, but work to maintain a psychological space analogous to the environmental provision the parent offers the child for safety and space to grow To this end, we offer regularity of boundaries and conditions, the fee, times of meeting, length of sessions, and other logistical matters that frame a psychological space within which we work Initially, it was difficult to hold Dennis Even though a steady frame of work had been established through setting up regular appointments, and beginning and ending on time, his anxious insecurity was expressed by his frequent urgent phone calls to me, trying to stay past the end of the sessions, and, sometimes, even appearing at my office between sessions Slowly, he internalized the regularity and continuity of the appointments and adapted to the frame I offered 2.

In Figure 4-2, arrows show the flows of money throughout the economy. Firms make payments rent, wages, interest and profits to households to obtain the factors of production land, labour, capital and entrepreneurship. (See the previous section Considering flows of income and assets for more information on these factors of production.) Households take the income they get from selling these factors and use it to pay for goods and services,

had been difficult for her She did not demand that he stop using Rick seemed to receive her input well I asked him if there were other reasons he thought his substance use was a problem, and he discussed some problems at work and his DUI incident To avoid conflict at home about prior substance use, I asked Rick and Liz to use therapy sessions as a controlled environment for any further discussion of past use A SSE SS M E N T A N D DI AG NOS I S When partners participate in treatment, they can be a helpful source of information about the amount of substance consumed, the topographical characteristics of consumption (rapidity, frequency, presentation of the drug for consumption), the social context, and typical locations of use Meyers et al.